Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.

Characterization of the Antiglioma Effect of the Oncolytic Adenovirus VCN-01.

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Despite the recent advances in the custom congratulations banner development of antitumor therapies, the prognosis for patients with malignant gliomas remains dismal.Therapy with tumor-selective viruses is emerging as a treatment option for this devastating disease.In this study we characterize the anti-glioma effect of VCN-01, an improved hyaluronidase-armed pRB-pathway-selective oncolytic adenovirus that has proven safe and effective in the treatment of several solid tumors.VCN-01 displayed a significant cytotoxic effect on glioma cells in vitro.

In vivo, in two different orthotopic glioma models, a single intra-tumoral administration of VCN-01 increased overall survival significantly and led to long-term survivors free click here of disease.